Villanova University reported an active shooter alert through its Nova Alert system on Thursday, urging students and staff to lock and barricade doors.
The university said to move to a secure location and stay clear of Law School Scarpa Hall.
The Radnor Township Police Department said it is at the scene and asked all nearby residents and students to shelter in place.
The university's security office told Fox News it is investigating.
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No additional details about the threat have been released.
Videos posted to social media appeared to show people scattered at an outdoor event.
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University records show a Class of 2029 student orientation was planned Thursday, including a family resource fair, opening mass and family picnic.
Villanova University is a private Catholic college located in Villanova, Pennsylvania.
The school is about 30 minutes outside Philadelphia.
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The incident comes weeks after an active shooter was reported Aug. 8 near Emory University's campus in Atlanta.
Gunman Patrick Joseph White, 30, took his own life after allegedly killing DeKalb County police officer David Rose, 33.
White is accused of shooting hundreds of rounds into six CDC buildings, though no employees were injured.
